BIOREGULATOR SERIES · UNDERGROUND KNOWLEDGE
The Khavinson
Bioregulator Series
25+ organ-specific peptides. 40 years of research. The most systematic approach to biological aging you've never heard of.
Explore the full system ↓What is the Bioregulator System?
In the 1970s, Soviet military scientists began a classified research program to protect personnel — soldiers, cosmonauts, submariners — from accelerated aging in extreme conditions. The program was led by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. What they built over 40 years, across 800+ peer-reviewed publications, is the most comprehensive organ-specific anti-aging system in existence.
The core theory: short peptides (2–4 amino acids) derived from specific organs can penetrate cell nuclei and interact directly with chromatin — acting as gene expression regulators for that specific tissue. Unlike most peptides that bind surface receptors, bioregulators are hypothesized to work epigenetically. Not a lock-and-key at the cell surface. A direct signal inside the nucleus.
The system comes in three forms. Cytomaxes are natural extracts from calf organs — the original form, broadest spectrum of activity, taken as oral enteric-coated capsules with a 6–12 month aftereffect. Cytogens are synthetic short peptides — the isolated active sequences, injectable, faster onset. Cytamins are tablet-form natural concentrates — the most accessible entry point.
Why does this matter for aging? Each organ has its own aging clock. The thymus involutes from your 20s. The pineal gland calcifies. Telomeres shorten in tissue-specific patterns. The bioregulator system treats the body as 25+ independent aging processes, each addressable by its organ-specific peptide. No other system does this with this level of specificity and research depth.
The honest evidence picture:most research comes from Khavinson's group and Russian clinical practice. Western-standard large RCTs are rare. The evidence is real and the system has been used clinically for decades — but epistemic humility applies here the same as everywhere on PepperLedger. 40 years of consistent findings from one research program. Compelling. Not yet independently replicated at Western clinical trial standards.
ORGAN MAP
The Organ System
29 compounds across 20+ organ systems. Hover to explore — click to open the compound guide.
Epithalon
CytogenPineal · AEDG
Telomerase activator — the most-studied longevity peptide bioregulator
Sigumir
CytomaxJoints
Cartilage and bone bioregulator — joint health and repair
Thymalin
CytomaxThymus
Full thymic peptide complex — 10-year human longevity data
Vesugen
CytogenVessels · KED
Vascular tripeptide — blood vessel integrity and circulation
Bronchogen
CytogenLungs · AEDL
Lung-specific bioregulator — respiratory health and protection
Cerluten
CytomaxBrain
Cytomax brain bioregulator — full CNS peptide complex
Chelohart
CytomaxHeart
Cardiac peptide bioregulator — heart muscle protection
Cortagen
CytogenNerves · AEDP
Peripheral nervous system bioregulator — neuroprotection and regeneration
Endoluten
CytomaxPineal
Pineal Cytomax — natural epithalamin complex; Cytomax counterpart to Epithalon
Glandokort
CytomaxAdrenal
Adrenal bioregulator — stress response and cortisol regulation
Livagen
CytogenLiver · KEDA
Liver and hematopoietic system cytogen — liver and blood cell support
Pinealon
CytogenBrain · EDR
Brain-specific neuroprotection and cognitive aging support
Suprefort
CytomaxPancreas
Pancreatic bioregulator — glucose metabolism and beta cell support
Svetinorm
CytomaxLiver
Liver bioregulator — detoxification and hepatic function
Vilon
CytogenThymus · KE
Thymic dipeptide — immune restoration and longevity
Bonomarlot
CytomaxMarrow
Bone marrow bioregulator — hematopoiesis and immune cell production
Bonothyrk
CytomaxParathyroid
Parathyroid bioregulator — calcium metabolism and bone density
Chitomur
CytomaxBladder
Bladder bioregulator — urinary tract health and mucosal protection
Chonluten
CytogenLung/Gut · GEP
Mucosal bioregulator — lung and gut epithelial protection
Gotratix
CytomaxMuscle
Muscle tissue bioregulator — skeletal muscle health and recovery
Libidon
CytomaxProstate
Prostate bioregulator — prostate health and male urological function
Pielotax
CytomaxKidneys
Renal peptide bioregulator — kidney function and protection
Stamakort
CytomaxStomach
Gastric peptide bioregulator — stomach mucosal protection
Taxorest
CytomaxLungs
Lung Cytomax — natural bronchial tissue complex
Testoluten
CytomaxTestes
Testicular bioregulator — male reproductive health and testosterone support
Ventfort
CytomaxVessels
Vascular Cytomax — natural blood vessel peptide complex
Visoluten
CytomaxEyes
Retinal peptide bioregulator — eye health and visual function
Vladonix
CytomaxThymus
Thymic Cytomax — natural thymus peptide complex
Zhenoluten
CytomaxOvaries
Ovarian bioregulator — female reproductive health and hormonal balance
THE THREE FORMS
Cytomax vs Cytogen vs Cytamin
| Cytomaxes | Cytogens | Cytamins | |
|---|---|---|---|
| Source | Natural animal organ extract | Synthetic peptide | Natural cytamine complex |
| Form | Oral enteric-coated capsule | Injectable (SC) | Oral tablet |
| Active components | Full organ peptide spectrum | Single isolated sequence | Full cytamine fraction |
| Onset | Slower, cumulative | Faster | Slowest |
| Aftereffect | 6–12 months post-course | Shorter | 3–6 months |
| Potency | Broadest (full spectrum) | Most targeted | Moderate |
| Best for | Long-term organ maintenance | Biohacker protocols | Entry-level / accessible |
| Evidence | 40+ years clinical use in Russia | Shorter track record | Extensive Russia use |
Most biohacker protocols use Cytogens (injectable synthetic sequences) for their targeted nature and faster onset. Cytomaxes are the original form with the deepest clinical use history. Understanding both is essential for reading the research literature correctly.
PROTOCOL GUIDE
How to Build a Bioregulator Protocol
Goal-based stacking framework. These are mechanistically-reasoned combinations, not clinically validated stacks — no controlled trials exist for combination bioregulator protocols. Treat as framework, not prescription.
Longevity Core — Start Here
Epithalon + Thymalin + Vesugen + Endoluten
Telomere maintenance + immune restoration + vascular health + pineal/circadian regulation — the four systems most directly driving biological aging.
Cognitive Longevity
Cortagen + Pinealon + Cerluten
Peripheral nerve protection + brain-specific neuroprotection + CNS Cytomax complex. Address cognitive aging from three angles simultaneously.
Immune Restoration
Thymalin + Vilon + Vladonix
Full thymic complex + dipeptide immune signal + thymic Cytomax. The thymus involutes from your 20s — this is direct thymic restoration.
Metabolic Optimization
Suprefort + Svetinorm + Stamakort
Pancreatic beta cell support + liver function + gastric mucosal protection. Three metabolic organs that decline with modern diet and aging.
Cardiovascular
Chelohart + Vesugen + Ventfort
Heart muscle protection + vascular peptide + blood vessel Cytomax complex. Full cardiovascular bioregulator approach.
Structural / Athletic
Sigumir + Gotratix + Bonomarlot
Cartilage and joint repair + skeletal muscle support + bone marrow and blood cell production.
Hormonal (Men)
Testoluten + Glandokort + Endoluten
Gonadal tissue + adrenal function + pineal regulation. Three endocrine axes most vulnerable to aging in men.
Hormonal (Women)
Zhenoluten + Glandokort + Endoluten
Ovarian tissue + adrenal function + pineal regulation. Hormonal aging support across the reproductive and stress axes.
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FULL REFERENCE
All 29 Compounds
| Compound | Organ | Type | Sequence | Guide |
|---|---|---|---|---|
| Epithalon | Pineal gland / telomeres | Cytogen | AEDG | Read → |
| Endoluten | Pineal gland | Cytomax | — | Coming soon |
| Pinealon | Brain / CNS | Cytogen | EDR | Read → |
| Cerluten | Brain / CNS | Cytomax | — | Coming soon |
| Visoluten | Retina / eyes | Cytomax | — | Coming soon |
| Cortagen | Nervous system | Cytogen | AEDP | Read → |
| Bonothyrk | Parathyroid | Cytomax | — | Covered here |
| Thymalin | Thymus complex | Cytomax | — | Read → |
| Vilon | Thymus | Cytogen | KE | Read → |
| Vladonix | Thymus | Cytomax | — | Covered here |
| Chelohart | Heart | Cytomax | — | Coming soon |
| Bronchogen | Lungs | Cytogen | AEDL | Read → |
| Taxorest | Lungs | Cytomax | — | Covered here |
| Vesugen | Blood vessels | Cytogen | KED | Read → |
| Ventfort | Blood vessels | Cytomax | — | Covered here |
| Stamakort | Stomach | Cytomax | — | Covered here |
| Svetinorm | Liver | Cytomax | — | Coming soon |
| Livagen | Liver / blood | Cytogen | KEDA | Coming soon |
| Chonluten | Lung / gut | Cytogen | GEP | Read → |
| Suprefort | Pancreas | Cytomax | — | Coming soon |
| Pielotax | Kidneys | Cytomax | — | Covered here |
| Glandokort | Adrenal glands | Cytomax | — | Covered here |
| Sigumir | Cartilage / joints | Cytomax | — | Read → |
| Gotratix | Skeletal muscle | Cytomax | — | Covered here |
| Bonomarlot | Bone marrow | Cytomax | — | Coming soon |
| Chitomur | Bladder | Cytomax | — | Covered here |
| Libidon | Prostate | Cytomax | — | Covered here |
| Testoluten | Testes | Cytomax | — | Covered here |
| Zhenoluten | Ovaries | Cytomax | — | Covered here |