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BIOREGULATOR SERIES · UNDERGROUND KNOWLEDGE

The Khavinson
Bioregulator Series

25+ organ-specific peptides. 40 years of research. The most systematic approach to biological aging you've never heard of.

Explore the full system ↓

What is the Bioregulator System?

In the 1970s, Soviet military scientists began a classified research program to protect personnel — soldiers, cosmonauts, submariners — from accelerated aging in extreme conditions. The program was led by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. What they built over 40 years, across 800+ peer-reviewed publications, is the most comprehensive organ-specific anti-aging system in existence.

The core theory: short peptides (2–4 amino acids) derived from specific organs can penetrate cell nuclei and interact directly with chromatin — acting as gene expression regulators for that specific tissue. Unlike most peptides that bind surface receptors, bioregulators are hypothesized to work epigenetically. Not a lock-and-key at the cell surface. A direct signal inside the nucleus.

The system comes in three forms. Cytomaxes are natural extracts from calf organs — the original form, broadest spectrum of activity, taken as oral enteric-coated capsules with a 6–12 month aftereffect. Cytogens are synthetic short peptides — the isolated active sequences, injectable, faster onset. Cytamins are tablet-form natural concentrates — the most accessible entry point.

Why does this matter for aging? Each organ has its own aging clock. The thymus involutes from your 20s. The pineal gland calcifies. Telomeres shorten in tissue-specific patterns. The bioregulator system treats the body as 25+ independent aging processes, each addressable by its organ-specific peptide. No other system does this with this level of specificity and research depth.

The honest evidence picture:most research comes from Khavinson's group and Russian clinical practice. Western-standard large RCTs are rare. The evidence is real and the system has been used clinically for decades — but epistemic humility applies here the same as everywhere on PepperLedger. 40 years of consistent findings from one research program. Compelling. Not yet independently replicated at Western clinical trial standards.

ORGAN MAP

The Organ System

29 compounds across 20+ organ systems. Hover to explore — click to open the compound guide.

PinealPinealBrainBrainEyesNervesParathyroidThymusThymusThymusHeartLungsLungsVesselsVesselsStomachLiverLiverLung/GutPancreasKidneysAdrenalJointsMuscleMarrowBladderProstateTestesOvaries
Hover an organ to explore

Epithalon

Cytogen

Pineal · AEDG

Telomerase activator — the most-studied longevity peptide bioregulator

Sigumir

Cytomax

Joints

Cartilage and bone bioregulator — joint health and repair

Thymalin

Cytomax

Thymus

Full thymic peptide complex — 10-year human longevity data

Vesugen

Cytogen

Vessels · KED

Vascular tripeptide — blood vessel integrity and circulation

Bronchogen

Cytogen

Lungs · AEDL

Lung-specific bioregulator — respiratory health and protection

Cerluten

Cytomax

Brain

Cytomax brain bioregulator — full CNS peptide complex

COMING SOON

Chelohart

Cytomax

Heart

Cardiac peptide bioregulator — heart muscle protection

COMING SOON

Cortagen

Cytogen

Nerves · AEDP

Peripheral nervous system bioregulator — neuroprotection and regeneration

Endoluten

Cytomax

Pineal

Pineal Cytomax — natural epithalamin complex; Cytomax counterpart to Epithalon

COMING SOON

Glandokort

Cytomax

Adrenal

Adrenal bioregulator — stress response and cortisol regulation

COMING SOON

Livagen

Cytogen

Liver · KEDA

Liver and hematopoietic system cytogen — liver and blood cell support

COMING SOON

Pinealon

Cytogen

Brain · EDR

Brain-specific neuroprotection and cognitive aging support

Suprefort

Cytomax

Pancreas

Pancreatic bioregulator — glucose metabolism and beta cell support

COMING SOON

Svetinorm

Cytomax

Liver

Liver bioregulator — detoxification and hepatic function

COMING SOON

Vilon

Cytogen

Thymus · KE

Thymic dipeptide — immune restoration and longevity

Bonomarlot

Cytomax

Marrow

Bone marrow bioregulator — hematopoiesis and immune cell production

COMING SOON

Bonothyrk

Cytomax

Parathyroid

Parathyroid bioregulator — calcium metabolism and bone density

COMING SOON

Chitomur

Cytomax

Bladder

Bladder bioregulator — urinary tract health and mucosal protection

COMING SOON

Chonluten

Cytogen

Lung/Gut · GEP

Mucosal bioregulator — lung and gut epithelial protection

Gotratix

Cytomax

Muscle

Muscle tissue bioregulator — skeletal muscle health and recovery

COMING SOON

Libidon

Cytomax

Prostate

Prostate bioregulator — prostate health and male urological function

COMING SOON

Pielotax

Cytomax

Kidneys

Renal peptide bioregulator — kidney function and protection

COMING SOON

Stamakort

Cytomax

Stomach

Gastric peptide bioregulator — stomach mucosal protection

COMING SOON

Taxorest

Cytomax

Lungs

Lung Cytomax — natural bronchial tissue complex

COMING SOON

Testoluten

Cytomax

Testes

Testicular bioregulator — male reproductive health and testosterone support

COMING SOON

Ventfort

Cytomax

Vessels

Vascular Cytomax — natural blood vessel peptide complex

COMING SOON

Visoluten

Cytomax

Eyes

Retinal peptide bioregulator — eye health and visual function

COMING SOON

Vladonix

Cytomax

Thymus

Thymic Cytomax — natural thymus peptide complex

COMING SOON

Zhenoluten

Cytomax

Ovaries

Ovarian bioregulator — female reproductive health and hormonal balance

COMING SOON

THE THREE FORMS

Cytomax vs Cytogen vs Cytamin

CytomaxesCytogensCytamins
SourceNatural animal organ extractSynthetic peptideNatural cytamine complex
FormOral enteric-coated capsuleInjectable (SC)Oral tablet
Active componentsFull organ peptide spectrumSingle isolated sequenceFull cytamine fraction
OnsetSlower, cumulativeFasterSlowest
Aftereffect6–12 months post-courseShorter3–6 months
PotencyBroadest (full spectrum)Most targetedModerate
Best forLong-term organ maintenanceBiohacker protocolsEntry-level / accessible
Evidence40+ years clinical use in RussiaShorter track recordExtensive Russia use

Most biohacker protocols use Cytogens (injectable synthetic sequences) for their targeted nature and faster onset. Cytomaxes are the original form with the deepest clinical use history. Understanding both is essential for reading the research literature correctly.

PROTOCOL GUIDE

How to Build a Bioregulator Protocol

Goal-based stacking framework. These are mechanistically-reasoned combinations, not clinically validated stacks — no controlled trials exist for combination bioregulator protocols. Treat as framework, not prescription.

Longevity Core — Start Here

Epithalon + Thymalin + Vesugen + Endoluten

Telomere maintenance + immune restoration + vascular health + pineal/circadian regulation — the four systems most directly driving biological aging.

Cognitive Longevity

Cortagen + Pinealon + Cerluten

Peripheral nerve protection + brain-specific neuroprotection + CNS Cytomax complex. Address cognitive aging from three angles simultaneously.

Immune Restoration

Thymalin + Vilon + Vladonix

Full thymic complex + dipeptide immune signal + thymic Cytomax. The thymus involutes from your 20s — this is direct thymic restoration.

Metabolic Optimization

Suprefort + Svetinorm + Stamakort

Pancreatic beta cell support + liver function + gastric mucosal protection. Three metabolic organs that decline with modern diet and aging.

Cardiovascular

Chelohart + Vesugen + Ventfort

Heart muscle protection + vascular peptide + blood vessel Cytomax complex. Full cardiovascular bioregulator approach.

Structural / Athletic

Sigumir + Gotratix + Bonomarlot

Cartilage and joint repair + skeletal muscle support + bone marrow and blood cell production.

Hormonal (Men)

Testoluten + Glandokort + Endoluten

Gonadal tissue + adrenal function + pineal regulation. Three endocrine axes most vulnerable to aging in men.

Hormonal (Women)

Zhenoluten + Glandokort + Endoluten

Ovarian tissue + adrenal function + pineal regulation. Hormonal aging support across the reproductive and stress axes.

CONTINUE IN THE APP

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FULL REFERENCE

All 29 Compounds

CompoundOrganTypeSequenceGuide
EpithalonPineal gland / telomeresCytogenAEDGRead →
EndolutenPineal glandCytomaxComing soon
PinealonBrain / CNSCytogenEDRRead →
CerlutenBrain / CNSCytomaxComing soon
VisolutenRetina / eyesCytomaxComing soon
CortagenNervous systemCytogenAEDPRead →
BonothyrkParathyroidCytomaxCovered here
ThymalinThymus complexCytomaxRead →
VilonThymusCytogenKERead →
VladonixThymusCytomaxCovered here
ChelohartHeartCytomaxComing soon
BronchogenLungsCytogenAEDLRead →
TaxorestLungsCytomaxCovered here
VesugenBlood vesselsCytogenKEDRead →
VentfortBlood vesselsCytomaxCovered here
StamakortStomachCytomaxCovered here
SvetinormLiverCytomaxComing soon
LivagenLiver / bloodCytogenKEDAComing soon
ChonlutenLung / gutCytogenGEPRead →
SuprefortPancreasCytomaxComing soon
PielotaxKidneysCytomaxCovered here
GlandokortAdrenal glandsCytomaxCovered here
SigumirCartilage / jointsCytomaxRead →
GotratixSkeletal muscleCytomaxCovered here
BonomarlotBone marrowCytomaxComing soon
ChitomurBladderCytomaxCovered here
LibidonProstateCytomaxCovered here
TestolutenTestesCytomaxCovered here
ZhenolutenOvariesCytomaxCovered here
PepperLedger

Educational tool — not medical advice. PepperLedger is a logging and information tool for adults managing their own protocols. It does not prescribe, diagnose, or treat anything. Always work with a qualified healthcare provider for medical decisions.

Educational tool — not medical advice. The Khavinson bioregulator series compounds are research chemicals in the United States and are not FDA-approved for any indication. Most published research comes from the Khavinson group at the Saint Petersburg Institute of Bioregulation and Gerontology. Independent Western-standard replication is limited. Approach with appropriate epistemic humility.

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